Production of Polycaprolactone/Atorvastatin Films for Drug Delivery Application

Developing biomaterials for tissue regeneration is a promising alternative the recovery of various tissues, including bone. Atorvastatin (ATV) has series beneficial effects which includes bone anabolism, vasodilating, and anti-inflammatory actions. The main objective this work was to produce characterize polycaprolactone (PCL) matrices incorporated with ATV. Samples were prepared by solvent casting technique. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) in vitro release studies performed. FTIR showed that no chemical bonds formed between PCL SEM amount ATV affects sample morphology. According XRD thermal analysis, characteristics maintained. PCL/ATV samples drug prolonged way since its reaches around 50% after 15000 minutes model best fit studied Higuchi model, correlation coefficient above 0.95.